Beclomethasone dipropionate ( Beclomethasone dipropionate | Clenil | Qvar | Beconase | alanase | Vancenase )

产品货号. M15010 CAS No. 5534-09-8

一种抗炎合成糖皮质激素。它局部用作抗炎剂，并以气雾剂形式用于治疗哮喘。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	￥251	有现货
200MG	￥373	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Beclomethasone dipropionate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

一种抗炎合成糖皮质激素。它局部用作抗炎剂，并以气雾剂形式用于治疗哮喘。
产品描述

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.(In Vitro):Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells.(In Vivo):Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number.
体外实验

Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells. Western Blot Analysis Cell Line:16HBE cells Concentration:1, 10 and 100 nM Incubation Time:20 min Result:Reduced the levels of iNOS, ROS and NT generated by rhIL-17A.
体内实验

Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number. Animal Model:Ten-week-old male Balb/c mice.Dosage:5 mg/kg (100 μg/ml for 60 min).Administration:Orally at 24 h and 1 h before the LPS aerosol.Result:Significantly (P < 0.05) inhibited the decrease of IL-10 level in BAL fluid induced by LPS exposure.Markedly reduced the release of both MMP-2 and MMP-9.Animal Model:Male BALB/c mice with asthma Dosage:150 μg/kg Administration:Nebulization Result:Decreased total cell number and relative eosinophil number in BALF.
同义词

Beclomethasone dipropionate | Clenil | Qvar | Beconase | alanase | Vancenase
通路

Endocrinology/Hormones
靶点

GR
受体

Glucocorticoid Receptor
研究领域

Inflammation/Immunology
适应症

——

化学信息

CAS Number

5534-09-8
分子量

521.04
分子式

C28H37ClO7
纯度

>98% (HPLC)
溶解度

DMSO: 10 mM
SMILES

CCC(O[C@]1(C(COC(CC)=O)=O)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C)=O)=O
化学全称

(8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate